It all depends on how much expansion you want to plan for. I assumed no more than 0.5 mm per cell. For your pack that would be 8 mm. 1/4" of foam is 6.35 mm thick. If you smash it flat it still has thickness, but even if it didn't it can't take 8 mm because it isn't even that thick.This still boggles my brain.. why would 4 cells be any different than 16 cells if more cells to do not apply anymore force to the 1/4 single piece of foam. Are you saying the psi would go above 18 with 16 cells if using one piece of 1/4” foam? if so I would think that could only happen if the extra 12 cells was causing there to be more force applied to the foam.......