Yes, wheels on one large box might actually be the easiest depending on how much the connectors TorC mentioned are, and also it might be easier for a first build. What models of BMS are verified to have two sense lead connectors?If you need 48v and portability, I agree with all the recommendations for a 16s BMS with the cells in multiple boxes.
If your lucky, your BMS is like this one with two sense lead connectors. Connect one to the negative half along with the main B - connection on the BMS. Run the second connector to a different box with the positive half of the cells and the B+ connection.
That way you just have one large cable and the BMS connector running between the two boxes.
Or wheels, wheels on one large box is the easiest.