The issue boils down to the insanely low internal resistance of many LiFePO4 batteries, and the Amp Interrupting Capacity of the fuse in question. If a wrench gets dropped across the bus bars, what happens?
For a moment, at least, you have a dead short. A battery pack like the 430AHr, 2p4s I’m building could temporarily drive upwards of 12,000A through the short. The only reasonably available fuse that can stop that is a Class T. With other fuses (MEGA, AMI, there’sa reasonable chance that when the fuse blows the resulting arc will continue to conduct through the plasma channel.
So, as such, you always need to select the proper fuse based on the design.