Batteries in series should be identical and at the same SOC in order to stay balanced. Trying to put the 4 100Ah 12V in 4P and the 2 200Ah 12V in 2P and then trying to put those two groups in series is likely to cause issues.
The original suggestion of putting the 4 100Ah 12V in 2S2P, the 2 200Ah 12V in 2S, and then putting those two groups in parallel with the 200Ah 24V will probably work much better.
Side note - battery capacities are measured in amp-hours (Ah), not amps (A).