As this is a skoolie and you probably have extra space, I'd definitely consider installing 2 inverters. This however increases idle consumption, not a huge problem in a stationary house with a large battery bank and large PV array. On an RV with limited roof real estate and a smaller battery bank, this might make things marginal if you ran into several cloudy days. One thing that can be done to reduce idle draw is to install remote switches if you don't need AC power 24/7. On my camper, I run a chest freezer/fridge which is DC powered and I don't have any other AC draws overnight so I can turn the inverter off.
If the units are inverter mini splits, then you probably could run just one inverter. The mini split in my living room never seems to draw over 1000W on initial cool down and it is a 1 ton 12K BTU unit. Running both at the same time with no other loads would be 2000W, well within the 6500W output rating.
If you haven't purchased any mini splits yet, then you have the choice between 240V units or 120V. The 240V units will always have a slightly higher SEER rating and you can run lighter wire. I prefer 240V units given a choice. On my truck camper, I am installing a 120V Senville 9K BTU unit because my system is setup for 30A.
If you already have the units, I'd install them, run some tests to see how many watts these take on shore power, then make a decision on whether you want to install 2 inverters or 1 nverter. 4000W of PV is about 1/2 of the size of my house array and I run a pair of LV6548's to power the house completely off grid with a 54Kwh battery bank. Spring, summer, fall I never run below 60% SOC so that should maybe help you decide if your system is large enough. The more battery you can install, the better you will be able to run anything you want and have power for a few days when PV yield is low without starting a generator.
2 inverters makes it easier to wire in for a 50A shore power connection. One inverter might limit you to 30A on shore power, that may or may not work out for you.