As gnubie noted, it's mainly convention. Switches, fuses, etc are usually conventionally placed on the positive side of any DC circuit (and the Active of an AC circuit), and many people - incl. me, tbh - would assume a switched positive in any given situation. i.e. you stick a meter probe on the chassis and take measurements/etc by poking your positive probe around the place. Also, installing battery management systems with current shunts, etc, that are designed for or assume high-side switching may unintentionally create a path that bypasses a low-side switching circuit. The moral here really is that you shouldn't assume things, but the reality is most people do, and thus there is a market to sell products that satisfy these assumptions.
To paraphrase pierre, if you are careful and understanding of your grounding then you'll be fine in any situation (essentially: if you tie to "ground" in more than one place you may have issues; zero places is of course less than one
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As to case isolation, you'd have to check the manual for your device. In the handful of devices I've played with (Victron and recent Renogy), the case is isolated from all inputs so you can do whatever you like in terms of mounting the device.