OP's question is one I am also asking as I am planning a new 24v inverter system for my trailer. The only advantage that I can see in using 2 x 12v in series is that it gives you the ability, in a pinch, to decouple the batteries, put them in parallel, and still be able to charge the batteries and feed the 12v DC loads if your DC to DC converter takes a crap while in the bush. That is if your battery power wires and fusing is sized appropriately. Also, as mentioned already, 12v replacements are much easier to come by in a pinch. I am thinking it might be easier to just carry a spare converter.