If you need 48v, then get or build an actual 48v battery. Some manufacturers are OK with series connecting their 12v LiFePO4 batteries, some aren't.
I doubt that the 280 Ah cells will fit your compartment, but just for comparison, I bought eight 280 Ah cells (including shipping, taxes, fees) for just over $900. That's 2.8 times the capacity of a 100 Ah cell for about the same money you're looking at in an off-the-shelf battery.
If it was me, I would max out the available space in the compartment with the largest cells I could buy.