My 2c, a van is relatively small, and most van builds make heavy use of 12v or 24v appliances/devices. For these reasons, the upside to 48V will be a bit more limited and the downsides will be a bit more of a bother.
Many of the popular brands and parts people use for vehicle and marine systems are 12/24v. I'm not just speaking of popular appliances like DC compressor fridges, I'm also talking about things like fuse blocks, circuit breakers and fuses, switches, lighting etc. Of course you can usually find alternatives online but it can still be a limitation, and takes more research/effort, alternatively you could get around this with DC-DC converters as you have proposed but then that comes with a conversion efficiency penalty and added costs. My feeling is until you are pushing up against limits of the lower voltages it makes sense to stick to them (not everyone shares this logic though).
What are the reasons you desire 48V over 24V (or 12V)?