Shale MacGregor
Solar Enthusiast
- Joined
- Sep 5, 2021
- Messages
- 641
Did you even read this? They theorize that it might work against covid, and then link to a study that used it at concentrations in vitro WAAAAY higher than you would ever be able to tolerate.Then you state that an anti-inflammatory is stopping viral replication without links? Cool!
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Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen
Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen - PubMed
Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of...pubmed.ncbi.nlm.nih.gov
The approved dose of ivermectin alone not useful in treating COVID-19
A new paper published on the preprint server medRxiv in April 2020 shows that the use of the already approved drug ivermectin in clinical trials to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)s not feasible. This contradicts earlier reports of its ability to suppress the...
www.news-medical.net
The in vitro study used ivermectin at a concentration that inhibits 50% of proliferating viruses (IC50). This concentration of 2 μM is 35 times higher than the maximum plasma concentration achieved in blood on oral administration of ivermectin at the approved dose of approximately 200 μg/kg. And this refers to the total plasma concentration.
Ivermectin is bound extensively by plasma protein, to the tune of 93%, which means that the maximum concentration of unbound ivermectin in the plasma is several orders of magnitude less.
So unless you are taking approximately grams of the stuff, it has no proven efficacy.