Simpler question might be what busbars are you going to use to connect the cells and where will the battery live? The smallest footprint for a battery is to compress them. If you don't compress then the standard busbars you get with the cells will not be safe to use since you will need some insulator between the cells and then using the busbars that come with them will just barely fit. Any expansion of cells in that scenario would put stress directly on the terminals. If you don't compress you can still use the standard busbars but you'll have to rearrange the cells so that they take up a lot more space.
As far as the basic general question of compressing or not watch this video to get basics of why some people compress and why some don't and it is still okay: